Drug Name Emsam (Selegiline) Drug Uses Emsam is a medicine, used for the treatment of depression. How Taken Use Emsam as directed by your doctor. Take Emsam with a full glass of water. Emsam can be taken with or without food. Ask your health care provider any questions you may have about how to use Emsam. Drug Class and Mechanism Emsam is a monoamine oxidase inhibitor (MAOI). Exactly how Emsam works to treat depression is unknown. Missed Dose If you miss a dose of Emsam, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Storage Store Emsam at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Emsam out of the reach of children and away from pets.